The story begins onboard a grounded plane that has just landed at New York's JFK airport. Police and emergency medical crews are called to investigate the possible outbreak of a mysterious disease, which has killed all but four of the plane's passengers. Unknowingly, something more ominous is responsible for the carnage, which now threatens the city and soon the entire country. Unlike the sexy bloodsuckers of paranormal romances and the cuddly vampires of teen fiction, these undead creatures are slick, dark, and frightening.