As the X-Men adjust to an influx of new students and the recent arrival at the Institute of their former enemy, Juggernaut, a squad of X-men is called to investigate a murder and, in the process, they uncover a plot to exterminate homo sapiens in favor of mutants.

Lowly class 'R' detective John Difool and his faithful companion, Deepo, are unwillingly hurled into yet another universe-saving mission, as their world is faced with the threat of an all-devouring metallic virus. Visionary storyteller Jodorowsky returns to the epic mythology he created with the late Mœbius in the early 80s. For the conclusion of the legendary spiritual space adventure series, he partners with Eisner-winning artist Ladrönn.

In the aftermath of 9/11, Captain America finds himself battling terrorism and Redpath when the latter orders his Extremists to cleanse the country by force.